Symbol
Name
ID

Dyrk1a
dual-specificity tyrosine phosphorylation regulated kinase 1a
MGI:1330299

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Microcephaly

Cerebral cortical atrophy

Ataxia

Incoordination

Delayed speech and language development

Happy demeanor

Inappropriate laughter

Autism

Hyperactivity

Motor stereotypy

Stereotypical hand wringing

Intellectual disability, severe

Gait disturbance

Severe global developmental delay

Seizure

Febrile seizure (within the age range of 3 months to 6 years)

Disease(s) Associated with DYRK1A

autosomal dominant intellectual developmental disorder 7

Mouse Phenotypes

environmentally induced seizures

abnormal brain size

decreased brain weight

increased brain weight

decreased hindbrain size

abnormal midbrain size

decreased midbrain size

decreased brain size

increased brain size

abnormal lateral ventricle morphology

abnormal third ventricle morphology

decreased superior colliculus size

small tectum

abnormal thalamus morphology

abnormal hippocampus morphology

abnormal dentate gyrus morphology

abnormal hippocampus molecular cell layer

abnormal hippocampus stratum oriens morphology

decreased hippocampus volume

abnormal cerebral hemisphere morphology

abnormal cerebral cortex pyramidal cell morphology

abnormal premotor cortex morphology

abnormal somatosensory cortex morphology

abnormal nervous system development

Availability

Mouse Genotype

Dyrk1a^tm1Mla/Dyrk1a^tm1Mla

Dyrk1a^em1Kzy/Dyrk1a⁺

Dyrk1a^tm1Mla/Dyrk1a⁺

Tg(Dyrk1a)189N3Yah/0

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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